Ho hlahisa PQQ: The Ultimate Energy Booster bakeng sa Kelello le 'Mele

Ho hlahisa PQQ: The Ultimate Energy Booster bakeng sa Kelello le 'Mele

Pyrroloquinoline quinone, e bitsoang PQQ, ke sehlopha se secha sa maiketsetso se nang le mesebetsi e tšoanang ea fisioloji ho livithamini. E fumaneha haholo ho prokaryotes, limela le liphoofolo tse anyesang, joalo ka soya e lomositsoeng kapa natto, pepere e tala, litholoana tsa kiwi, Parsley, tee, papaya, spinach, celery, lebese la matsoele, joalo-joalo.

Lilemong tsa morao tjena, PQQ e fetohile e 'ngoe ea limatlafatsi tsa "naleli" tse hohetseng tlhokomelo e atileng. Ka 2022 le 2023, naha ea heso e ile ea amohela PQQ e hlahisoang ka ho kopanya le ho belisoa e le lisebelisoa tse ncha tsa lijo.

Mesebetsi ea tlhaho ea PQQ e tsepamisitsoe haholo likarolong tse peli. Ntlha ea pele, e ka tšehetsa khōlo le nts'etsopele ea mitochondria le ho susumetsa khōlo e potlakileng ea lisele tsa motho; ea bobeli, e na le thepa e ntle ea antioxidant, e ka thusang ho tlosa li-radicals tsa mahala le ho fokotsa tšenyo ea lisele. Mesebetsi ena e 'meli e etsa hore e be le karolo e matla ho bophelo bo botle ba boko, bophelo bo botle ba pelo, bophelo bo botle ba metabolic le likarolo tse ling. Hobane 'mele oa motho ha o khone ho iketsetsa PQQ ka boeona, o hloka ho tlatselletsoa ka li-supplement tsa lijo.

Karolo ea 01.PQQ ea ho ntlafatsa temoho e bohlokoa haholo

Ka Hlakola 2023, bafuputsi ba Majapane ba ile ba hatisa pampiri ea lipatlisiso e bitsoang "Pyrroloquinoline quinone disodium salt e ntlafatsa ts'ebetso ea boko ho batho ba baholo le ba baholo" makasineng ea "Food & Function", ho hlahisa tsebo ea PQQ ho bacha le batho ba baholo ba Japane. Liphetho tsa lipatlisiso tse ntlafalitsoeng.

Phuputso ena e ne e le teko e laoloang ka mokhoa o sa sebetseng ea li-placebo tse sa boneng habeli tse neng li kenyelletsa banna ba Majapane ba phetseng hantle ba 62 ba lilemo li 20-65, ba nang le lintlha tsa Mini-Mental State Scale ≥ 24, ba bolokileng bophelo ba bona ba pele nakong ea thuto. Letšoele la basali. Lithuto tsa lipatlisiso li arotsoe ka mokhoa o sa reroang ka sehlopha sa ho kenella le sehlopha sa taolo ea placebo, 'me li ne li tsamaisoa ka molomo PQQ (20 mg / d) kapa li-capsules tsa placebo letsatsi le leng le le leng bakeng sa libeke tsa 12. Sistimi ea tlhahlobo ea inthaneteng e ntlafalitsoeng ke k'hamphani e ile ea sebelisoa bakeng sa boitsebahatso libekeng tsa 0/8/12. Teko ea kelello e lekola mesebetsi e 15 e latelang ea boko.

Liphello li bontšitse hore ha li bapisoa le sehlopha sa taolo ea placebo, ka mor'a libeke tsa 12 tsa ho noa PQQ, mohopolo o kopantsoeng le lintlha tsa mohopolo oa mantsoe a lihlopha tsohle le sehlopha sa maqheku li ile tsa eketseha; kamora libeke tse 8 tsa ho ja PQQ, ho tenyetseha ha kelello ha sehlopha se senyane, lebelo la ts'ebetso le lebelo la Phethahatso li ile tsa eketseha.

02 PQQ e ke ke ea ntlafatsa ts'ebetso ea boko ba maqheku feela, empa hape e ntlafatsa karabelo ea boko ba bacha!

Ka Hlakubele 2023, koranta e tsebahalang lefatšeng ka bophara Food & Function e phatlalalitse pampiri ea lipatlisiso e bitsoang "Pyrroloquinoline quinone disodium letsoai e ntlafatsa ts'ebetso ea boko ho batho ba baholo le ba banyenyane". Boithuto bona bo fuputsa phello ea PQQ tšebetsong ea kelello ea batho ba baholo ba lilemo tse 20-65, ho holisa palo ea batho ba ithutoang ba PQQ ho tloha ho maqheku ho ea ho bacha. Boithuto bona bo pakile hore PQQ e ka ntlafatsa ts'ebetso ea kelello ea batho ba lilemo tsohle.

Patlisiso e fumane hore PQQ, joalo ka lijo tse sebetsang hantle, e ka ntlafatsa ts'ebetso ea boko ho lilemo life kapa life, mme e lebelletsoe ho holisa ts'ebeliso ea PQQ joalo ka lijo tse sebetsang ho tloha ho maqheku ho ea ho batho ba lilemo tsohle.

03 PQQ e sebetsa e le activator ea "cell energy lifeme" ho tsosolosa bophelo ba bona

Ka Mots'eanong 2023, Cell Death Dis e phatlalalitse pampiri ea lipatlisiso e bitsoang Botenya bo sitisa mitophagy e itšetlehileng ka cardiolipin le bokhoni ba phetisetso ea li-intercellular mitochondrial ea lisele tsa mesenchymal stem. Boithuto bona bo sibollotse PQQ ka ho lekola hore na bokhoni ba bafani ba li-intercellular mitochondrial ba batho ba batenya (batho ba nang le mathata a metabolic) le phello ea kalafo ea lisele tsa mesenchymal stem (MSCs) ha ba na bothata, le hore na kalafo e lebisitsoeng ho mitochondrial e ka li khutlisa. Ho feto-fetoha ha molumo ho khutlisetsa bophelo bo botle ba mitochondrial ho fokotsa ho fokola ha mitophagy.
Boithuto bona bo fana ka kutloisiso ea pele e felletseng ea limolek'hule tsa mitophagy e holofetseng ka har'a lisele tsa mesenchymal stem tse tsoang ho botenya mme e bonts'a hore bophelo bo botle ba mitochondrial bo ka khutlisoa ka melaoana ea PQQ ho fokotsa bothata ba mitophagy.

04 PQQ e ka ntlafatsa ts'ebetso ea metabolism ea motho

Ka Mots'eanong 2023, sengoloa sa tlhahlobo se bitsoang "Pyrroloquinoline-quinone ho fokotsa ho bokellana ha mafura le ho matlafatsa botenya" se ile sa hatisoa koranteng ea Front Mol Biosci, e akaretsang lithuto tse 5 tsa liphoofolo le lithuto tse peli tsa lisele.
Liphetho li bonts'a hore PQQ e ka fokotsa mafura a 'mele, haholo-holo ho bokellana ha mafura a visceral le sebete, ka hona ho thibela botenya ba lijo. Ho tsoa tlhahlobong ea molao-motheo, PQQ e thibela haholo lipogenesis mme e fokotsa ho bokellana ha mafura ka ho ntlafatsa ts'ebetso ea mitochondrial le ho khothaletsa metabolism ea lipid.

05 PQQ e ka thibela lefu la ho fokola ha masapo le bakoang ke botsofali ba tlhaho

Ka Loetse 2023, Aging Cell e ile ea hatisa pampiri ea lipatlisiso e bitsoang "Pyrroloquinoline quinone e kokobetsa lefu la ho fokola ha tlhaho le amanang le botsofali ka buka ea MCM3-Keap1-Nrf2 axis-mediated stress response le Fbn1 upregulation" inthaneteng. Boithuto bona, ka liteko tsa litoeba, bo fumane hore li-supplement tsa PQQ tsa lijo li ka thibela lefu la masapo le bakoang ke botsofali ba tlhaho. Mochini oa motheo oa matla a matla a antioxidant a PQQ o fana ka motheo oa liteko oa tšebeliso ea PQQ joalo ka tlatsetso ea lijo bakeng sa thibelo ea lefu la masapo le amanang le lilemo.
Boithuto bona bo senola karolo e sebetsang le mokhoa o mocha oa PQQ ho thibela le ho alafa lefu la ho fokola ha masapo, 'me e paka hore PQQ e ka sebelisoa e le tlatsetso ea lijo e bolokehileng le e sebetsang ho thibela le ho alafa senile osteoporosis. Ka nako e ts'oanang, ho ile ha senoloa hore PQQ e kenya tšebetsong lets'oao la MCM3-Keap1-Nrf2 ho li-osteoblasts, e hatisa ka mokhoa o hlakileng polelo ea liphatsa tsa lefutso tsa antioxidant le liphatsa tsa lefutso tsa Fbn1, e thibela khatello ea maikutlo ea oxidative le osteoclast bone resorption, mme e khothalletsa ho thehoa ha masapo a osteoblast, ka hona ho thibela botsofali. karolo ketsahalong ea lefu la ho fokola ha thobalano.

06 Ho tlatselletsa PQQ ho ka sireletsa lisele tsa retinal ganglion le ho ntlafatsa bophelo bo botle ba mahlo!

Ka September 2023, koranta ea Acta Neuropathol Commun e ile ea hatisa phuputso e tsoang ho litsebi tse amanang le ophthalmology le litsebi tse tsoang Sepetleleng sa Eye sa Karolinska Institutet se Stockholm, Sweden, sekolo se tummeng sa bongaka sa Europe, hammoho le Royal Victoria Eye and Ear Hospital e Australia, le Lefapha la Biology ea Univesithi ea Pisa Italy. E bitsoa "Pyrroloquinoline quinone drives ATP synthesis in vitro le in vivo mme e fana ka retinal ganglion cell neuroprotection." Patlisiso e pakile hore PQQ e na le ts'ireletso liseleng tsa retinal ganglion (RGC) mme e na le bokhoni bo boholo joalo ka moemeli e mocha oa "neuroprotective" ho hanela retinal ganglion cell apoptosis.
Liphuputso li ts'ehetsa karolo e ka bang teng ea PQQ joalo ka sesebelisoa sa "neuroprotective" se ncha se ka ntlafatsang botsitso ba lisele tsa retinal ganglion ha se ntse se fokotsa kotsi ea litlamorao tse ka bang teng. Ka nako e ts'oanang, bafuputsi ba lumela hore ho tlatsa PQQ ke khetho e sebetsang ea ho boloka bophelo bo botle ba mahlo.

07 Ho tlatsetsa PQQ ho ka laola limela tsa mala, ho ntlafatsa tšebetso ea qoqotho, le ho fokotsa tšenyo ea qoqotho.

Ka December 2023, sehlopha sa lipatlisiso se tsoang Sepetleleng sa Batho sa Leshome sa Shanghai sa Sekolo sa Bongaka sa Tongji se ile sa hatisa sengoloa se reng "Karolo e ka bang Teng ea Pyrroloquinoline Quinone ho Laola Ts'ebetso ea Thyroid le Gut Microbiota Sebopeho sa Mafu a Mabitla ho Litoeba" koranteng ea Pol J Microbiol Sengoliloeng sena, bafuputsi ba bonts'a hore florite ea PQ e tlatselletsa mohlala oa PQ. fokotsa ho senyeha ha mala, le ho ntlafatsa mosebetsi oa qoqotho.
Boithuto bona bo fumane litlamorao tsa tlatsetso ea PQQ ho litoeba tsa GD le limela tsa tsona tsa mala:

01 Ka mor'a tlatsetso ea PQQ, serum TSHR le T4 ea litoeba tsa GD li ile tsa fokotsoa, ​​​​'me boholo ba qoqotho ea qoqotho bo fokotsehile haholo.

02 PQQ e fokotsa ho ruruha le khatello ea oxidative, hape e fokotsa tšenyo ea mala a manyane.

03 PQQ e na le phello e kholo ho tsosoloseng mefuta-futa le sebopeho sa microbiota.

04 Ha ho bapisoa le sehlopha sa GD, phekolo ea PQQ e ka fokotsa bongata ba Lactobacilli ho litoeba (ena ke phekolo e ka lebelloang bakeng sa ts'ebetso ea GD).

Ka kakaretso, tlatsetso ea PQQ e ka laola ts'ebetso ea qoqotho, ea fokotsa tšenyo ea qoqotho, 'me ea fokotsa ho ruruha le khatello ea oxidative, kahoo ea fokotsa tšenyo ea mala a manyane. 'Me PQQ e ka boela ea tsosolosa mefuta-futa ea limela tsa mala.

Ntle le lithuto tse kaholimo tse pakang karolo ea bohlokoa le bokhoni bo sa lekanyetsoang ba PQQ joalo ka tlatsetso ea lijo ho ntlafatsa bophelo bo botle ba batho, lithuto tse fetileng le tsona li tsoetse pele ho netefatsa mesebetsi e matla ea PQQ.

08 PQQ e ka ntlafatsa khatello ea mali ea pulmonary

Ka Mphalane 2022, pampiri ea lipatlisiso e bitsoang "Pyrroloquinoline quinone (PQQ) e ntlafatsa khatello ea mali ea pulmonary ka ho laola mesebetsi ea mitochondrial le metabolic" e phatlalalitsoe koranteng ea Pulmonary Pharmacology & Therapeutics, ka sepheo sa ho hlahloba karolo ea PQQ ho ntlafatsa khatello ea mali ea matšoafo.
Liphetho li bonts'a hore PQQ e ka fokotsa ho se tloaelehe ha mitochondrial le ho se tloaelehe ha metabolic liseleng tsa mesifa ea pulmonary artery le ho liehisa tsoelo-pele ea khatello ea mali ea matšoafo ho likhoto; ka hona, PQQ e ka sebelisoa e le sesebelisoa sa kalafo se ka bang teng ho ntlafatsa khatello ea mali ea pulmonary.

09 PQQ e ka liehisa botsofali ba lisele le ho lelefatsa bophelo!

Ka Pherekhong 2020, pampiri ea lipatlisiso e bitsitsoeng Pyrroloquinoline quinone e liehisa ho ruruha ho bakoang ke TNF-α ka p16/p21 le litselana tsa matšoao tsa Jagged1 tse phatlalalitsoeng ho Clin Exp Pharmacol Physiol e netefalitse ka kotloloho phello ea anti-botsofali ea PQQ liseleng tsa motho. , liphetho li bontša hore PQQ e liehisa botsofali ba lisele tsa motho mme e ka eketsa nako ea bophelo.

Bafuputsi ba fumane hore PQQ e ka liehisa botsofali ba lisele tsa motho, 'me ea netefatsa qeto ena ka liphetho tsa li-biomarker tse ngata tse kang p21, p16, le Jagged1. Ho khothaletsoa hore PQQ e ka ntlafatsa bophelo bo botle ba sechaba le ho lelefatsa nako ea bophelo.

10 PQQ e ka thibela botsofali ba mahe le ho boloka tsoalo

Ka Hlakubele 2022, pampiri ea lipatlisiso e bitsitsoeng "PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice" e ile ea hatisoa koranteng ea Front Endocrinol, ka sepheo sa ho ithuta hore na li-supplement tsa phepo ea PQQ li sireletsa khahlanong le ho se sebetse hantle ha mae a bomme. phello.
Liphetho li bonts'itse hore tlatsetso ea PQQ e ekelitse boima ba 'mele le boholo ba mae a bomme, ea khutlisa potoloho e senyehileng ea estrous,' me ea thibela tahlehelo ea li-follicle ho litoeba tse tšoaroang ka li-alkylating agents. Ho feta moo, tlatsetso ea PQQ e ekelitse sekhahla sa boimana le boholo ba matlakala ka ho beleha ho litoeba tse alafiloeng ke li-alkylating. Liphetho tsena li totobatsa monyetla oa ho kenella oa tlatsetso ea PQQ ho ho se sebetse ha mae a bomme a alkylating agent.

Qetello
Ebile, joalo ka tlatsetso e ncha ea lijo, PQQ e amohetsoe ka litlamorao tsa eona tse ntle ho phepo le bophelo bo botle. Ka lebaka la mesebetsi ea eona e matla, tšireletso e phahameng le botsitso bo botle, e na le menyetla e pharaletseng ea tsoelo-pele tšimong ea lijo tse sebetsang.
Lilemong tsa morao tjena, ka ho teba ha tsebo, PQQ e fihletse setifikeiti sa katleho e felletseng mme e sebelisoa haholo joalo ka tlatsetso ea lijo kapa lijo United States, Europe le linaheng tse ling le libaka. Ha tlhokomeliso ea bareki ba malapeng e ntse e eketseha, ho lumeloa hore PQQ, joalo ka motsoako o mocha oa lijo, e tla theha lefatše le lecha 'marakeng oa lehae.

Litšupiso:

1.TAMAKOSHI M, SUZUKI T, NISHIHARA E, et al. Pyrroloquinoline quinone disodium letsoai le ntlafatsa ts'ebetso ea boko ho batho ba baholo le ba baholo [J]. Lijo le Mosebetsi, 2023, 14 (5): 2496-501.doi: 10.1039/d2fo01515c.2. Masanori Tamakoshi,Tomomi Suzuki,Eiichiro Nishihara,et al. Pyrroloquinoline quinone disodium letsoai le ntlafatsa ts'ebetso ea boko ho batho ba baholo le ba banyenyane. Teko e Laoloang ka Randomized Mosebetsi oa Lijo. 2023 Mar 6;14(5):2496-2501. PMID: 36807425.3. Shakti Sagar,Md Imam Faizan,Nisha Chaudhary,et al. Botenya bo sitisa mitophagy e itšetlehileng ka cardiolipin le bokhoni ba phetisetso ea mitochondrial ea phekolo ea lisele tsa mesenchymal stem. Cell Death Dis. 2023 May 13;14(5):324. doi: 10.1038/s41419-023-05810-3. PMID: 37173333.4. Nur Syafiqah Mohamad Ishak , Kazuto Ikemoto. Pyrroloquinoline-quinone ho fokotsa ho bokellana ha mafura le ho ntlafatsa tsoelo-pele ea botenya. FrontMolBiosci.2023May5:10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340.5.Jie Li, Jing Zhang, Qi Xue, et al. Pyrroloquinoline quinone e kokobetsa lefu la ho fokola ha tlhaho le amanang le botsofali ka buka e reng MCM3-Keap1-Nrf2 axis-mediated stress response le Fbn1 upregulation. Botsofali Cell. 2023 Sep;22(9):e13912. doi: 10.1111/acel.13912. Epub 2023 Jun 26. PMID: 37365714.6. Alessio Canovai, James R Tribble, Melissa Jöe. le. al. Pyrroloquinoline quinone e tsamaisa synthesis ea ATP in vitro le in vivo mme e fana ka tšireletso ea lisele tsa retinal ganglion. Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. PMID: 37684640.7. Xiaoyan Liu , Wen Jiang , Ganghua Lu , et al. Karolo e ka khonehang ea Pyrroloquinoline Quinone ho Laola Mosebetsi oa Thyroid le Gut Microbiota Sebopeho sa Mafu a Graves ho Litoeba. Pol J Microbiol. 2023 Dec 16;72(4):443-460. doi: 10.33073/pjm-2023-042. eCollection 2023 Dec 1. PMID: 38095308.8. Shafiq, Mohammad et al. "Pyrroloquinoline quinone (PQQ) e ntlafatsa khatello ea mali ea matšoafo ka ho laola mesebetsi ea mitochondrial le metabolism." Pulmonary pharmacology & therapeutics vol. 76 (2022): 102156. doi:10.1016/j.pupt.2022.1021569. Ying Gao, Teru Kamogashira, Chisato Fujimoto. le al. Pyrroloquinoline quinone e liehisa ho ruruha ho bakoang ke TNF-α ka p16/p21 le litsela tsa lipontšo tsa Jagged1. Clin Exp Pharmacol Physiol. 2020 Jan;47(1):102-110. doi: 10.1111/1440-1681.13176. PMID: 31520547.10.Dai, Xiuliang et al. "PQQ Tlatsetso ea Lijo e Thibela Ho se sebetse ha Ovary e Bakiloeng ke Alkylating Agent ho Litoeba." Frontiers in endocrinology vol. 13 781404. 7 Mar. 2022, doi:10.3389/fendo.2022.781404